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This observation is in contrast to the investigations conducted by Wang and Chen (2023 49 and Zhao et al

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doi: 10.1016/j.aca.2021.338267 96 MagginiS.PierreA.CalderP

Leijten JC, Georgi N, Wu L, van Blitterswijk CA, Karperien M

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The lack of MRS dACC changes in the Recent onset group in this or other studies does not amount to a decisive refutation of the glutamate neurotoxicity hypothesis because the relationship of static MRS glutamate to synaptic status is too uncertain and the time of onset of the putative glutamate excess relative to psychosis onset is unknown
