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Hepatic system : ROS-mediated damage, neutrophil activity, and ischemic hypoperfusion drive hepatocellular necrosis and inflammation
2.4.3 Signaling pathway alterations Beyond activating inflammatory and cell death cascades, overwhelming oxidative stress pathologically alters numerous other intracellular signaling pathways crucial for myocardial function and survival
doi: 10.3390/nu7053536 127 BuettnerGR

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Nitric oxide and neurological disorders
& Pedersen, P