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doi:10.1053/j.anndiagpath.2004.04.003

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Bogenrieder T, Rogler G, Vogt T, Landthaler M, Stolz W: Orofacial granulomatosis as the initial presentation of Crohn's disease in an adolescent

Clinical question: What are the clinical features of an atypical melanoma

The characteristic of these elements is that they are a little swollen and have a rather voluminous nucleus, easily recognizable also to the hematoxylin-eosin, round, sometimes with incisions, with a particularly evident nucleolus, with a conspicuous Golgi apparatus because they carry out synthesis and assembly of melanin, and within the cytoplasm there is the presence of granules (melanosomes) which are of various sizes but almost always roundish, more or less loaded with melanin