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Population Doubling Level Calculation To calculate the PDL, a formula was used as follows: n = 3.32 (log UCY log I ) + X , where n is the final PDL at the end of a given subculture, UCY is the cell yield at that point, I is the cell number used as inoculum to begin that subculture, and X is the PDL of the inoculum used to initiate the subculture being quantitated (Pham et al., 2020)

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In deeply anesthetized rats, laparatomized before sacrifice, we assessed the gross lesions in the gastrointestinal tract and in the stomach (sum of the longest diameters, mm) ( Liver and Spleen Weights Liver and spleen weights are expressed as a percentage of total body weight (for normal rats, liver, 3.24.0%

What we know Over 68 weeks, the safety profile remained stable