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The neoantigen with strong immunogenicity is derived from tumor mutant protein

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Now known as the FoyerHalliwellAsada pathway, this sequence of reactions notably links reduction of H 2 O 2 , catalysed by ascorbate peroxidase, to oxidation of NADH or NADPH, catalysed by monodehydroascorbate reductase and glutathione reductase

Recent studies have shown that upregulation of FAO occurs predominantly in conditions of nutrient deprivation, with dual inhibition of FAO (using etomoxir) and glucose metabolism (using 2-deoxy-D-glucose [2-DG]) yielding significant benefits in animal models of glioma [123]

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doi: 10.1016/j.neubiorev.2012.02.013 7