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The trouble starts when it is injected instead
The AF will further differentiate into the inner AF, a region that exhibits characteristics of fibrous tissue and cartilage, and outer AF, a primarily fibrous region (Van den Akker et al., 2017)
An example is azathioprine
Nature 2011;479, 232-236, doi:10.1038/nature10600

Each combination creates a different frequency consideration

2018 ESC/ESH guidelines for the management of arterial hypertension