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Acutely, ethanol serves as both a substrate for and inhibitor of CYP2E1, limiting the amount of NAPQI formed
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, Kim1 expression increased with higher doses of sulfasalazine (Supplemental Figure 6), suggesting a dose-dependent nephrotoxic effect
Research documents stimulation of multiple matrix components including collagen, dermatan sulfate, chondroitin sulfate, and decorin
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