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The molecular mechanisms remain to be elucidated
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[45] However, reactive oxygen species might also mediate beneficial training adaptations as a part of a biologically useful signaling cascade
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PIK3CA mutations induced in the MCF10A human mammary epithelial cell line result in a 50% increase in glutamine uptake and a significant increase in glutamate production (195)
however, research has indicated that its efficacy was likely unrelated to ASCT2 inhibition, yielding again to the problem of non-specificity [108]
