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10.1016/j.anai.2021.02.026 Ann Allergy Asthma Immunol

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A and tau appear to act synergistically to damage the OXPHOS system, with tau damaging complex I and A damaging complex IV [78]

Overexpression of NNMT in adipose tissue directly correlates with reduced NAD+ availability, impaired mitochondrial function, and diminished cellular energy expenditure

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