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In addition to oligonucleotide therapeutics, some small-molecule NNMT inhibitors have been reported recently [5659] and several have shown effectiveness in the prevention or treatment of obesity and T2D in vitro [60, 61] or in preclinical animal models [10, 58, 62], validating NNMT as a pharmacological drug target

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[10] Hydroxocobalamin is available as a generic medication

We are not simply giving a shot

SIRT1 is NAD-dependent meaning it requires adequate NAD levels to function

I agree