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Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain

In a study conducted by Tsacopoulos et al

The reference lists of the retrieved publications were also searched for additional relevant published and unpublished studies, including conference abstracts

Therapeutic approaches aimed at T-cell polarization, such as restoring Treg function or suppressing Th17 signaling, have shown promise in preclinical DKD models, suggesting potential pathways for immune modulation

While it inhibits fibrosis by activating the Keap1-Nrf2 pathway and downregulating the phosphorylation of Smad3 and STAT3, the interactions among involved signaling pathways (such as PI3K/Akt, MAPK, TGF-, Wnt/-catenin) and their roles at different pathological stages have not been systematically studied

Ghazale A, Chari ST, Zhang L, et al
