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[DOI] [PubMed] [Google Scholar] 59.Ferrante K.L., Shefner J., Zhang H., Betensky R., OBrien M., Yu H., Fantasia M., Taft J., Beal M.F., Traynor B., et al

We found that lactate, taken up and oxidized by the mitochondrial cluster of differentiation 147 (CD147)/monocarboxylate transporter 1 (MCT1)/lactate dehydrogenase B (LDHB) complex, was converted into the tricarboxylic acid (TCA) cycle intermediate -ketoglutaric acid (-KG), which subsequently induced MIC stemness potentials via DNA methyltransferase 3 beta (DNMT3B)-mediated SOX2 hypomethylation

Immune System Support: Strengthens white-blood-cell function to guard against illness

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Ioannidi et al., 2009