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Jiao Cheng (73) found that melatonin could suppress OS-induced HIF-1/ROS/VEGF signaling and inhibit the proliferation of endothelial cellsindicating that the activation of HIF-1 is an important angiogenic process

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43 In addition to biomechanical factors, the molecular biophysics of the ACL plays a crucial role in understanding injury mechanisms and developing effective prevention and treatment strategies

Interestingly, SAPs hydrogels can also safely encapsulate cells or drugs for specific therapies (Zhan et al., 2013