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Limitations This method measures total glutathione rather than providing spatial or subcellular resolution

Back to Journals Clinical, Cosmetic and Investigational Dermatology Volume 10 Glutathione and its antiaging and antimelanogenic effects Authors Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P Received 21 November 2016 Accepted for publication 10 February 2017 Published 27 April 2017 Volume 2017:10 Pages 147153 DOI Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Jeffrey Weinberg Sinee Weschawalit, 1 Siriwan Thongthip, 2 Phanupong Phutrakool, 3 Pravit Asawanonda 1 1 Department of Medicine, Division of Dermatology, 2 Chula Clinical Research Center, 3 Chula Data Management Center, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Background: Previous studies showed that supplementation of reduced form of glutathione (GSH, 500 mg/d) has a skin-lightening efficacy in humans

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Caffeine: Too much caffeine may hinder the effects of glutathione

While 0 generally indicated no changes, the lesions were subsequently scored as follows: 0-3, edema (1- weak diffuse and/or perifocal