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Similarly, in vitro experiments, approximately 45 bacterial phylotypes were identified to enhance GLP-1 secretion through exposure of NCI H716 L-cells to their cell-free culture supernatants (Tomaro-Duchesneau et al., 2020), co-incubation of Caco-2 cells with Enterococcus faecalis or Mitsuokella multacida supernatants led to a significant reduction in GLP-1 mRNA expression ( E

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A report from the EMAs PRAC, published on 12 April 2024, said: After reviewing the available evidence from non-clinical studies, clinical trials, post-marketing surveillance data and the available studies the PRAC considers that no update to the product information is warranted. The PRAC statement said that market authorisation holders would continue to monitor events, including new studies, as part of their pharmacovigilance activities