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Referral to secondary care is indicated for severe or rapidly progressive neurological symptoms, diagnostic uncertainty, suspected bone marrow failure, or in pregnancy or paediatric cases

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Cons: Requires needles and proper injection technique

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Chronic Alcohol Use: Associated with reduced absorption

However, the supplying of IID through co-expression fails to rescue the formation of an intact polymerase complex due to its relatively low binding affinity for MARL (Supplementary Fig