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The primary sources of ROS production in the central nervous system (CNS) are mitochondrial proteins, NADPH oxidase, Rac1, and SOD1 (Nayernia et al., 2014
In the liver, a 60 kDa carboxylesterase hydrolyzes much of the compound to 5'-deoxy-5-fluorocytidine (5'-DFCR)
These residues are absent in the sequences of the other human Na + -independent OCTs and OATs surveyed (Supplementary Fig
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