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Beyond imparting preferential ZSWIM8 binding, the trigger RNA could also enhance catalytic efficiency through additional means, such as by orienting AGO lysine residues for more rapid ubiquitylation, or by increasing the processivity of polyubiquitylation

10.1038/jcbfm.2013.71 164 SagguR.SchumacherT.GerichF.RakersC.TaiK.DelekateA.et al