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The proliferative responses may be due, in part, to increased activation of extracellular signal-related kinase 1/2 (ERK1/2) pathways in the double knockout cells

Interestingly, recent studies indicate that in the setting of ATII-induced hypertension, a downregulation of the dihydrofolate reductase was observed, which was accompanied by decreased vascular BH 4 levels and an uncoupled eNOS, 91 implicating a potential role of this salvage pathway in the development of hypertension

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It is noteworthy that the Mediterranean diet, which has been allied with many health benefits, is characterized by a high intake of fruits, vegetables and nuts containing several bioactive natural products of plants

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doi: 10.1038/s41573-021-00195-4