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While same mitochondrial problems are present in the UMNs of ALS patients with TDP-43 pathology and UMNs of TDP-43 mouse models, and since pathologies are shared at a cellular level, regardless of species, we first analyzed the metabolite profile of both healthy and diseased motor cortex to investigate whether metabolomic changes occur with respect to TDP-43 pathology

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Epithalon is a synthetic tetrapeptide derived from amino acid sequences associated with pineal-related peptide structures and has been studied in laboratory settings in relation to cellular signalling and peptide interaction models

Targeting this pathway offers a promising strategy for cancer therapy, especially in combination with other treatments

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PMID: 35697807