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Notably, the SA-driven glutathione system not only directly scavenges ROS but also regenerates vitamin C/E, establishing an amplified antioxidant network [61]
It is widely accepted that in addition to T cells, monocyte/macrophage lineage cells are among the first cells targeted by HIV 6 and these cells then allow the virus to spread rapidly by transmission to CD4 + T cells 7,8,9
The phosphorylation level of Thr484 couples cardiac contraction to the processing of precursor proteins by regulating SR calcium recycling, thereby maintaining normal cardiac function [248]
Dysbiosis and impaired barrier function increase the translocation of microbe-associated molecular patterns, such as LPS, which can induce a systemic inflammatory state and the release of cytokines such as IL-6 and TNF- (101)
10.1016/j.ymthe.2022.06.016 46 ZhouY.WuQ
Co-Expression of TIGIT and Helios Marks Immunosenescent CD8(+) T Cells During Aging
