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doi: 10.1152/ajpgi.00314.2002

doi: 10.1210/jcem-73-5-1081 88 VeldhuisJDIranmaneshAHoKKWatersMJJohnsonMLLizarraldeG

If you plan to resume, restart at the full dose rather than titrating back up, since the break period allows receptor resensitization

For histological analysis, the femoral and tibial condyles were fixed in 10% neutral buffered formalin, decalcified with 20% EDTA, embedded in paraffin, and sectioned into 5-m thick frontal slices

doi: 10.1006/exnr.2002.7909

Answer: Glutathione and Vitamin C can start showing skin lightening effects within 2-6 weeks, but noticeable results typically take 3-6 months of consistent use
