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Bone effects Blood cells including immune cells like B cells are produced by cells in the bones

10.1016/j.vph.2018.02.010 100 VukojeviJ.VrdoljakB.MalekinuiD.SiroglaviM.MilaviM.KolencD.et al (2020)

Structural analyses were supported by Italian Association for Mitochondrial Research resources made available by ReCaS, a project funded by the MIUR (Italian Ministry for Education, University and Research) in the PON Ricerca e Competitivit 20072013-Azione I-Interventi di rafforzamento strutturale PONa3_00052, Avviso 254/Ric, University of Bari (Fondi Ateneo ex-60%2016

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Consistent with this, depleting mouse skeletal muscle NAD + levels by 85% did not affect muscle function, muscle aging, or organismal aging (Chubanava et al., 2025)