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Inhibition of the gut microbial CutC/D, the TMA-generating enzyme reduced the plasma TMAO levels and rescued the platelet hyper responsiveness and thrombus formation in animal models

Nature 365: 6569, 1993

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OEA binds directly to LBP-8, a lysosomal lipid chaperone that activates nuclear hormone receptors NHR-49/PPAR- and NHR-80/HNF4 regulating genes involved in -oxidation and fatty acid desaturation, respectively [35, 68]

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However, these tools are not useful to determine cPKC activation status in tumor samples