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The capacity of developing nervous system to generate spontaneous activity in absence of external stimulation is a remarkable feature that has been observed in particular in the retina, the cerebral cortex, the hippocampus, the cerebellum, the hindbrain, and the spinal cord [14]

10.1371/journal.pone.0177181 400 WojcikC.RowickaM.KudlickiA.NowisD.McconnellE.KujawaM.et al

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Regarding the ligands of E3 ligases less recruited by PROTACs, such as KEAP1 or DCAF, the existing ligands are still scarce, with low affinities and little studied

10.3389/fphar.2019.01321 272 WangF

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