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4.2.2 ROS-independent NETosis and inflammasome-related amplification loops Besides the classic oxidative stress pathways, studies indicate that MSU crystals can also directly induce histone citrullination and NET formation through the TAK1/SYK/PAD4 axis or by directly activating the NF-B pathway, thereby bypassing the classic ROS burst (110, 112)

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline Solubility: 2.5 mg/mL (11.45 mM)

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Blood pressure targets may also be adjusted based on the patients baseline BP and clinical signs of perfusion