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When taken as a supplement, L-Carnitine enters the bloodstream and supports the transport of fatty acids into cells for energy production

Gene Therapy: Emerging gene-editing technologies such as CRISPR-Cas9 hold promise for correcting FMO3 gene mutations, offering a potentially curative approach for TMAU in the future [18]

One of the major concerns is that the intestinal metabolism of L-carnitine generates trimethylamine-N-oxide (TMAO), a compound that has been linked with faster atherosclerosis progression

This is often a short-term condition

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The US National Kidney Foundation did not recommend routine administration of L-carnitine to subjects undergoing dialysis yet encouraged the development of trials in patients with select symptoms that do not respond to standard therapy, i.e., persistent muscle cramps or hypotension during dialysis, severe fatigue, skeletal muscle weakness or myopathy, cardiomyopathy, and anemia requiring large doses of erythropoietin (74, 75)