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This rule also proposes recalibration of the PDGM case-mix weights and updates the low utilization payment adjustment (LUPA) thresholds, functional impairment levels, comorbidity adjustment subgroups for CY 2023 and the fixed-dollar loss ratio (FDL) used for outlier payments

AOD-9604 lacks this broad receptor engagement, confining its research activity to lipolytic pathways, which makes it a more targeted and mechanistically distinct compound for metabolic research models

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