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10,278 Genetic suppression of the IKK/NF-B pathway, achieved through the deletion of one p65 allele, or pharmacological intervention via IKK inhibitors, such as 8K-NBD, has been shown to delay the onset and mitigate the severity of aging symptoms and age-related pathologies in the nervous system of murine models 10,279

[DOI] [Google Scholar] 89.Lin A.M.Y., Feng S.F., Chao P.L., Yang C.H

Reduced concentrations of inflammatory cytokines, including IL-2 and IL-1, were also reported

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[PubMed: 16430706] 245

These include its impact on hormonal signaling pathways like GnRH and prolactin, its role in activating enzymatic processes that affect testosterone synthesis, its modulation of androgen receptor sensitivity, and its protection against oxidative stress and homocysteine toxicity