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doi:10.1002/jcp.27101

Therapy resistance: modulating evolutionarily conserved heat shock protein machinery in cancer

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However, excessive ammonia accumulation induces a novel form of cell death in effector T cells, termed Ammonia death ( Distinct from traditional cell death mechanisms such as apoptosis, necrosis, and pyroptosis, ammonia-induced cell death (termed Ammonia death) is a novel form of cell death triggered by overload of glutamine-derived ammonia, leading to the demise of effector T cells

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