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Finally, two ketothiolase (with a CoA-acyltransferase) generate acetyl CoA and a new acyl-CoA two atoms shorter, which continues through the cycle as far as octanoate, which can then be subjected to mitochondrial -oxidation

10.1007/s002530100773 [DOI] [PubMed] [Google Scholar] Buckel W., Keese R

Because BH 4 is involved in additional critical hydroxylation reactions, notably tryptophan hydroxylation by tryptophan hydroxylase and tyrosine hydroxylation by tyrosine hydroxylase it is important to correctly diagnose any HPA as being the result of abnormal BH 4 homeostasis or defects in PAH

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[Google Scholar] Graudins A, Aaron CK

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