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Topical phenylephrine, used in-office for iris dilation, and its prodrugs dipivefrin and apraclonidine have been documented to induce AACG [2] Topical anticholinergic/cycloplegics agents used for pupillary dilation may also lead to AACG [2] [1] Botulinum act at peripheral cholinergic synapses, inhibiting the release of acetylcholine

In that case, recheck ALT and AST at 8 weeks to confirm downward trend

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2016 PMC4819426 Storb, R