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[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Fasano, C., Disciglio, V., Bertora, S., Lepore Signorile, M

In the absence of intracellular nucleophiles such as GSH, this reactive metabolite ( N -acetylbenzoiminoquinone) not only reacts with nucleophilic groups of cellular proteins resulting in direct hepatocellular damage, but also participates in redox cycling, thereby generating reactive O 2 species ( ROS ) and consequent oxidative stress that greatly enhance APAP-induced hepatotoxicity

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10.3390/nu6020466 14 GalliF.BonominiM.BartoliniD.ZatiniL.ReboldiG.MarcantoniniG.et al (2022)

83 Each protomer of this homodimeric transporter comprises nine transmembrane helices and three metal ions