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Exposure to cold temperatures activates production of proteins including RNA-binding motif protein 3 (RBM3), which demonstrates neuroprotective effects and may help maintain muscle mass during periods of reduced activity

however, their bioavailability is low,22 and long term efficacy studies in symptomatic B 12 deficiency are lacking

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Using metabolic markers of B12 status like methylmalonic acid and homocysteine to aid in the diagnosis of clinically manifested vitamin B12 deficiency has advantages, but also shortcomings [10,11], such as the high costs of measurements, the limited availability, and the impact of renal insufficiency on the concentrations