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On the other hand, arsenic exposure has been demonstrated to activate the transcriptional activity of HIF-2, which in turn promotes dual oxidase 1 (DUOX1) expression

doi: 10.1016/j.nano.2019.102117 2

Jos Fbio Santos Duarte Lana, Email: [email protected]

All PDB structures underwent preprocessing including the addition of missing amino acid atoms and hydrogens, removal of solvent atoms, and hydrogen-bond network optimization and residue protonation based on predicted pKa values using the Protein Preparation Wizard 51 of Maestro Schrdinger Release 2018-1 [Maestro, Schrdinger, LLC, New York, NY, 2018]

Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress

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