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Cartilage cells, particularly chondrocytes, produce catabolic factors such as cytokines (IL-6, IL-8), chemokines (RANTES, IP-10), metalloproteases (MMP1, MMP3), and heat-shock proteins (HSPA1A), which serve as biomarkers for the onset and progression of knee OA

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The long-term tick challenge showed that the Vanguard crLyme vaccine did not induce sterile immunity like the RABV-vector vaccine constructs