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Serious risks include pancreatitis and a potential risk of thyroid C-cell tumors

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10.1073/pnas.1911837116 292

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Oxidative stress may happen partly through the involvement of translocation and activation of mitochondrial NOX4 [235], CYP2E1-generated ROS [68, 210, 236], HFD-mediated insulin resistance [22], and various PTMs of mitochondrial proteins, causing mitochondrial dysfunction, decreased fat degradation, and elevated hepatocyte death [49]

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