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The Therapeutic Use Exemption Program It should be noted that athletes who have a legitimate medical reason for using a prohibited substance or method that is on the List can apply for a Therapeutic Use Exemption (TUE) to determine whether they meet the criteria outlined in the International Standard for Therapeutic Use Exemptions (ISTUE)

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Dysfunction of the gut microbiota not only causes a variety of gastrointestinal diseases, such as diarrhea, constipation, and enteritis, but can also induce chronic diseases, such as obesity, cardiovascular disease, diabetes, and metabolic syndrome (Marchesi et al., 2016