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Importantly, P4-induced slowing of hypothalamic GnRH pulse frequency during the luteal phase alters downstream pituitary signaling dynamics, reinforcing the cyclical alternation between estrogen-dominant and P4-dominant endocrine states [26]
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doi: 10.1038/ng1762
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These studies have also shown that ICA-1s is specific to PKC -, leaving normal cells that do not overexpress PKC - largely unaffected 1,3
