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We then converted the network to a minimum spanning network to identify alterations in other metabolites that GC analysis did not reveal

This step is the rate-limiting step in GSH production, and GCL is feedback inhibited by GSH itself (78)

& Bailey-Serres, J
40mcg (as L-selenomethionine) Proprietary Blend
21 Vomiting and vertigo are the next most frequently experienced symptoms and, like nausea, both illustrate a dose-dependent increase in frequency

Details for RNA-Seq reads mapping are described in Supplemental Methods
