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Klicek R, Sever M, Radic B, et al
Weight loss during this period averages 2-5 pounds, primarily from reduced caloric intake and initial water loss

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The New EU HTA Framework Creates New Evidence Requirements Since becoming applicable in January 2025, the EU Health Technology Assessment (HTA) Regulation has significantly increased the focus on patient-centered outcomes and real-world evidence as key components of reimbursement, market access, and healthcare decision-making across Europe
