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TMAO-induced inflammation and endothelial dysfunction in human umbilical vein endothelial cells (HUVECs) can be reversed by treatment with the ROS inhibitor N-acetylcysteine (NAC) or by siRNA-mediated knockdown of NLRP3, suggesting that TMAO exerts its pro-inflammatory effects via the ROS/NLRP3 inflammasome [146]

Erythematous Rash of the Face and Scalp In the prospective study by Autier et al.,13 an erythematous facial rash very similar to classic seborrheic dermatitis was observed in 63% of patients treated with sorafenib, compared with 2% of patients in the control group

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