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The lupine seed protein congly-g stimulates the specific pathway PKC/Flotillin-2/caveolin-3/Cbl to activate glucose homeostasis and increase glucose transport (94)

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This is followed by further phosphorylation of two additional docking tyrosine residues in the carboxy terminal tail (Tyr1349 and Tyr1356) which on activation can act as degenerate motif to recruit several other subsequent signaling molecules

Ohanian M, Kantarjian HM, Quintas-Cardama A, Jabbour E, Abruzzo L, Verstovsek S, Borthakur G , Ravandi F, Garcia-Manero G, Champlin R, Pierce S, Alattar ML, Trinh LX, Luthra R, Ferrajoli A, Kadia T, O'Brien S, Cortes JE