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One study found that the use of ferroptosis inhibitors and glutaminolysis inhibitors inhibited erastin-induced ferroptosis, resulting in an increase in intracellular GSH and a decrease in intracellular ROS content, thus finding that glutamine and GLS2 are required for the development of cellular ferroptosis

This would include a sophisticated innate and adaptive defense system to counter environmental insults successfully

These observations were confirmed in vivo, where combining vitamin C reduced tumor xenograft growth of SW620 cells but not that of HCT116 cells

Cuervo AM, Bergamini E, Brunk UT, Droge W, Ffrench M, Terman A

A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport (42)

Having said that, GSH-based medication has also been successfully employed to protect against cisplatin induced nephrotoxicity