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8 Both the 2012 NIH Evidence-Based Methodology Workshop on PCOS and the 2018 International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome recommend use of the Rotterdam criteria for the diagnosis of PCOS with the additional identification of the specific PCOS phenotype

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The interaction very rarely results in a pernicious anemia that appears reversible with discontinuation of metformin or with Methylcobalamin, vitamin B12 supplementation

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