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PF-4191834 has also completed phase II (NCT00723021) clinical trial for asthma but phase II for knee osteoarthritis was terminated due to a serious adverse event (NCT01147458) such as syncope, acute hepatitis, and gastric ulcer hemorrhage

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Furthermore, Fraxin, Poria cocos and albumin-bound sphingosine-1-phosphate can reduce MMP levels, thereby alleviating glycocalyx damage

227,229 In AD, autophagy defects mediate the disruption of protein homeostasis networks (production and extracellular secretion of A, abnormal aggregation of tau protein) and lead to the accumulation of damaged organelles, such as dysfunctional mitochondria