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The IB kinase (IKK) complex is activated by TNF- and other cell stressors through a series of intermediate stages that result in IkB phosphorylation and ubiquitination, which in turn causes IkB degradation and activates NF-B followed by nuclear translocation to bind a specific DNA sequence (As Jr 1996

[DOI] [PubMed] [Google Scholar] 180.Gaillard S., Jacquet H., Vavasseur A., Leonhardt N., Forestier C

The results of our study suggest that reduction of intracellular copper by chelating therapy to reduce copper overload might be a novel therapeutic target for prevention and treatment of renal fibrosis