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Electrolyte used for electrochemical measurements was an aCSF prepared by mixing KCl (2.4 mM), NaCl (126 mM), KH 2 PO 4 (0.5 mM), NaHCO 3 (27.5 mM), MgCl 2 (0.85 mM), CaCl 2 (1.1 mM), and Na 2 SO 4 (0.5 mM), with the pH adjusted to 7.4

Meta-analysis of randomized controlled trials shows L-carnitine supplementation significantly reduces CRP (weighted mean difference -1.23 mg/L), IL-6 (-0.85 pg/dL), and TNF- (-0.37 pg/dL), with greater effects observed in studies exceeding 12 weeks duration.[4] In obese patients, L-carnitine combined with synbiotics reduced IL-6 by 34%, hs-CRP by 10%, TNF- by 19%, and malondialdehyde by 22%.[5] L-carnitine also improves inflammatory markers in chronic kidney disease, cardiovascular disease, and metabolic conditions.[6] Acetyl-L-carnitine offers distinct advantages for neuroinflammation through multiple mechanisms beyond simple carnitine delivery

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PubMed Central , doi:10.17179/excli2016-485

Renal dopamine receptors, oxidative stress, and hypertension

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