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The striatum, particularly the medium spiny neurons of the caudate nucleus and putamen, is the earliest and most severely affected brain region

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The binding of Wnts to the LRP/Frizzled receptor complex rescues -catenin from phosphorylation by the destruction complex (Axin2/APC/GSK3) and escapes the proteasomal degradation

Mutti, Institute of Clinical Medicine and Nephrology, University of Parma, Parma, Italy a a Attended 6 December 1989 only

Prolonged pretreatment with -lipoic acid protects cultured neurons against hypoxic, glutamate-, or iron-induced injury