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Pathological oxysterols can displace or promote an increase in cholesterol oxidization, leading to reduced GABA A receptor surface stability and faster receptor internalization reducing inhibition (Sooksawate and Simmonds, 1998

Studies have found that supplementing 5002,000 mg of vitamin C per day can support glutathione recycling and help replenish the antioxidant pool 27

Prog Lipid Res

The reason for this odd behavior likely comes down to the fact that the immune system is relatively quiescent when we are well but ramps up production of disease-fighting cells and antibodies very rapidly in response to disease

Thus, SP and MH were selected for further validation

In addition, FIN56 is capable of binding and activating squalene synthase, and leads to depleting coenzyme Q10 (CoQ10) (Shimada et al., 2016), which is a vital antioxidant by directly reducing lipid peroxyl radicals ( 2 , which is able to oxidate iron and indirectly inactivate GPX4, thus inducing lipid peroxidation in an ALOX-independent manner (Gaschler et al., 2018)